742-AlphaCell: for Simulating Cellular Perturbation Dynamics
The paper introduces AlphaCell, a generative "World Model" designed to simulate how human cells react to various genetic and chemical treatments. Traditional computational models often struggle with accuracy because they only track a small fraction of genes and fail to capture the complex, continuous nature of cellular changes. AlphaCell overcomes these hurdles by processing the entire protein-coding transcriptome and mapping it into a unified, mathematical Virtual Cell Space. This framework utilizes a massive Mixture-of-Experts decoder to ensure that digital simulations can be translated…
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