330-COAST: Image-Guided Multi-Modal Spatial Tissue Alignment
The paper introduces COAST (Consecutive multi-Omics Alignment of Spatial Tissues), a novel computational method for accurately aligning consecutive tissue sections analyzed by different spatial omics technologies. COAST exclusively utilizes paired staining images (like H&E or nuclear stains) to create a shared feature space for alignment, eliminating the need for matching molecular profiles or prior annotations common in other methods. The paper rigorously benchmarks COAST's performance against existing uni-modal alignment tools using spatial transcriptomics data, demonstrating comparable or…
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