265-High-Resolution Atlas of Hematopoietic Progenitors
The paper details a comprehensive study employing a unified multimodal single-cell framework to redefine hematopoiesis, the process of blood cell formation, in mice. Researchers integrated transcriptional (RNA), surface protein (CITE-seq, InfinityFlow), and chromatin accessibility (TEA-seq) data to identify and characterize discrete hematopoietic progenitor cell states, particularly the rare Multilineage (MultiLin) cells. This approach, using the ChromLinker computational framework, revealed hierarchical gene regulatory networks (GRNs) driving cell fate decisions and allowed for the isolation…
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