1566-Multimodal Brain Cell Atlas of Adult Macaque Lifespan

Paper Talk · Sep 11, 2026 · 26m

This study presents a comprehensive single-cell multi-omic atlas documenting the aging process within the brains of non-human primates. Researchers analyzed over 1.4 million nuclei from various brain regions in macaques to track changes in gene expression and chromatin accessibility across their lifespan. The findings highlight how specific neuronal and glial cell types exhibit different vulnerabilities, including altered synaptic signaling and neuroinflammatory responses. Notably, the research identifies conserved aging patterns shared between macaques and humans while also noting divergent…