Latest / Decera Clinical Education Oncology Podcast
Targeting CDH6 in Platinum-Resistant Ovarian Cancer: Emerging ADCs, Biomarkers, and Sequencing
In this podcast episode, BJ Rimel, MD, and Elizabeth Lee, MD, discuss the scientific rationale for targeting CDH6 in ovarian cancer and the emerging role of CDH6-directed antibody–drug conjugates (ADCs) in platinum-resistant disease, including:
CDH6 biology, expression patterns, and its potential as a therapeutic target in ovarian cancer
Early-phase efficacy data with investigational CDH6-directed ADCs, including raludotatug deruxtecan (R-DXd) and CUSP06, and an ongoing phase III trial of R-DXd
Safety considerations with CDH6-directed ADCs, including cytopenias, gastrointestinal toxicities…
The skinny
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