1468-Dendritic Cells as Orchestrators of Cancer TLS
The research article examines how mature type 1 conventional dendritic cells (cDC1s) act as the primary architects and keepers of tertiary lymphoid structures (TLSs) in cancerous environments. Using advanced spatial transcriptomics and mouse models, the study demonstrates that these immune cells undergo IFN-γ-driven maturation to initiate the early formation of lymphoid aggregates. As tumors advance, mature cDC1s migrate into specific stromal hubs within the tumor to maintain the structural integrity and functionality of the TLS. The researchers established that antigen presentation to both…
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