Micro 51: Reoviruses
This episode explores the reoviruses, a family of non-enveloped double-stranded RNA viruses with segmented genomes. Drawing from Murray’s Chapter 51, it focuses primarily on rotavirus, a leading cause of severe gastroenteritis in infants and young children.
Reoviruses are structurally distinctive: they possess multiple protein layers forming a double capsid shell that protects the segmented RNA genome. Because double-stranded RNA is a potent trigger of innate immune responses, replication occurs within partially intact capsids in the cytoplasm, shielding viral RNA from detection.
The…
The skinny
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