564-Sensory Neurons Drive Immune Exclusion in Breast Cancer
This research investigates how perineural invasion (PNI) serves as a critical driver of treatment resistance in triple-negative breast cancer (TNBC). The studies reveal that sensory neurons within the tumor microenvironment release a signaling molecule called CGRP, which interacts with fibroblasts to promote excessive collagen deposition. This structural reorganization creates a physical barrier that prevents immune cells from attacking the tumor, thereby shielding the cancer from immunotherapy. Clinical data from multiple cohorts confirm that higher nerve density correlates with poorer…
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