Latest / Fork U with Dr. Terry Simpson / How Ozempic Works and Why Diets Still Matter

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How Ozempic Works and Why Diets Still Matter · Fork U with Dr. Terry Simpson

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  >> Dr. Terry Simpson: Chances are you know someone who has been on
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  Ozempic.
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  >> Dr. Terry Simpson: Maybe you've heard someone whisper at brunch.
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  >> Dr. Terry Simpson: That they're on the shot.
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  >> Dr. Terry Simpson: Or maybe you've seen some of the headlines about some of the miracles that.
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  >> Dr. Terry Simpson: The GLP1s like Ozempic and Zeppbound can
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  do.
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  >> Dr. Terry Simpson: Today we're going to talk about those.
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  >> Dr. Terry Simpson: GLP1 Ozempic, also known as
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  WeGovy, Zeppbound.
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  >> Dr. Terry Simpson: Also known as Terzepzide or Manjaro. These are
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  not diet pills. These are precision
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  metabolic therapies.
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  >> Dr. Terry Simpson: And no, the real magic is not in your
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  gut. The real magic is in your
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  brain.
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  >> Dr. Terry Simpson: I'm your Chief Medical Explanationist, Dr. Terri.
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  >> Dr. Terry Simpson: Simpson, and this is Fork U Fork
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  University, where we make sense of the madness,
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  bust a few myths, and teach you a little bit about food
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  and medicine.
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  >> Dr. Terry Simpson: Here's how the GLP1s work.
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  >> Dr. Terry Simpson: Work in your brain.
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  >> Dr. Terry Simpson: Now, if you remember neuroanatomy, you are.
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  >> Dr. Terry Simpson: Going to love the next three sentences.
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  If not, just hang in there. You'll learn some
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  fancy words and it's okay to use them.
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  GLP ones work in something called the
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  hypothalamus, where they activate satiety
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  neurons and suppress hunger. Got that so
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  far. Right. In the mesolimbic
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  reward system, the ventral.
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  >> Dr. Terry Simpson: Tigeminal area and the nucleus accumbens, they.
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  >> Dr. Terry Simpson: Reduce dopamine release, blunting food's
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  reward effect. They also modulate
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  serotonin, impacting mood, reducing.
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  >> Dr. Terry Simpson: Emotional eating, and improving satiety.
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  >> Dr. Terry Simpson: Okay, you got through it.
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  >> Dr. Terry Simpson: Here's the bottom.
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  >> Dr. Terry Simpson: Food noise is gone.
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  When you hear people saying that, they're not just
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  manifesting, they are describing, uh, a
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  complex neurochemistry that
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  we have never heard before,
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  people talking about food noise being gone.
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  >> Dr. Terry Simpson: We've also seen it in patients who've taken these drugs, and
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  they've noticed that.
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  >> Dr. Terry Simpson: They have a decreased interest in alcohol
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  or tobacco. There are more things that
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  GLP1s do, and we're going to talk about some of those a little
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  bit.
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  >> Dr. Terry Simpson: But these drugs literally
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  rewire the drive to eat.
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  It's not just a sensation of fullness.
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  What makes them transformative is in the brain.
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  It's not the nausea, it's not the gastric slowing.
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  >> Dr. Terry Simpson: Those help, but that's not the primary
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  mechanism.
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  >> Dr. Terry Simpson: And now I want to address the.
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  >> Dr. Terry Simpson: Influencer lie or quack lie of the Week.
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  >> Dr. Terry Simpson: You've seen them. Natural GLP1 Boosters
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  or Buy youy Natural GLP1. The
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  reason these quacks have that form is because the
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  pharmaceutical companies are still.
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  >> Dr. Terry Simpson: Charging too much for the GLP1s.
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  >> Dr. Terry Simpson: But yes, let's start with the obvious. Your body
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  produces GLP1. It produces it in the
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  distal part of the small bowel. And fiber
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  rich foods which change your microbiome
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  enhance the production of your own natural
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  GLP1. And we also
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  discovered that some ultra processed junk
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  foods not only blunt production of
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  GLP1, but they actually
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  destroy the cells.
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  >> Dr. Terry Simpson: Well, the food doesn't.
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  >> Dr. Terry Simpson: The food causes you to have an increase in a certain
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  bacteria which actually.
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  >> Dr. Terry Simpson: Destroy cells that make your own
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  GLP1. What about your
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  GLP1?
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  >> Dr. Terry Simpson: It is metabolized in minutes.
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  >> Dr. Terry Simpson: It's cleared by an enzyme called DPP4.
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  >> Dr. Terry Simpson: Long before it ever reaches your brain.
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  Semaglutide, on the other hand, is synthetic.
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  It stays active in your body for days.
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  It's engineered so it can cross the blood brain
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  barrier, bind to the receptors.
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  >> Dr. Terry Simpson: And the reward centers, and actually help.
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  >> Dr. Terry Simpson: You change your behavior.
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  >> Dr. Terry Simpson: Think about this. If you are trying
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  to dig a trench and you have
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  a little tiny shovel like one of those you use.
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  >> Dr. Terry Simpson: In the garden, it's going to take you forever. You're going to get discouraged and
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  you're.
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  >> Dr. Terry Simpson: Going to give up.
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  >> Dr. Terry Simpson: Get a backhoe. You can do it quickly.
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  >> Dr. Terry Simpson: GLP1s are like the backhoe.
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  >> Dr. Terry Simpson: What about sea moss and berberine and all these other
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  fiber things?
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  >> Dr. Terry Simpson: They don't do that.
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  >> Dr. Terry Simpson: If they did, if they could last long in
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  your body, they'd be prescription drugs.
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  >> Dr. Terry Simpson: But instead they're Instagram ads.
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  >> Dr. Terry Simpson: Let's talk about some myths and lies and TikTok
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  tragedies.
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  >> Dr. Terry Simpson: Myth one, it's a cheat code.
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  >> Dr. Terry Simpson: Nope.
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  >> Dr. Terry Simpson: This does not erase responsibility.
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  It makes responsible choices
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  finally possible. Myth
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  two, you're gonna lose your muscle mass.
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  >> Dr. Terry Simpson: Well, if your diet is err and.
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  >> Dr. Terry Simpson: Regret, yeah, it will.
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  >> Dr. Terry Simpson: But if you eat a reasonable amount of protein, do some lifting,
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  or do.
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  >> Dr. Terry Simpson: Some resistance training, you're gonna be fine.
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  >> Dr. Terry Simpson: M Myth three, you're gonna regain it.
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  >> Dr. Terry Simpson: All when you stop.
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  >> Dr. Terry Simpson: You know, if you treat this like a crash diet.
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  Absolutely. If you use it to help
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  reset behavior and adjust your lifestyle.
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  Not necessarily. But uh, remember,
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  GLP1s are a treatment for
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  obesity. And just like a treatment for blood pressure
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  medicine, when your blood pressure gets under control, you don't
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  stop your blood pressure medicine. When your lipids get under control,
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  you don't stop your cholesterol medicine. When your
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  obesity gets under control, you.
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  >> Dr. Terry Simpson: Don'T stop your GLP1.
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  >> Dr. Terry Simpson: Myth four, it causes cancer. Well,
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  if you're a rodent and take.
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  >> Dr. Terry Simpson: Megadoses of it, you're going to have some thyroid issues,
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  but not in humans.
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  >> Dr. Terry Simpson: That's not your worry unless you have a rare genetic
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  ailment called Men2 syndrome, which
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  if you're an adult, you know you have it by now and you probably should
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  not be on a GLP1 unless you're very well
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  supervised, or if.
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  >> Dr. Terry Simpson: You'Ve ever had a type of thyroid.
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  >> Dr. Terry Simpson: Cancer called medullary thyroid cancer.
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  >> Dr. Terry Simpson: Myth 5 It's totally safe.
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  >> Dr. Terry Simpson: Nothing is totally safe.
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  Some suggestions have even suggested a possible link to
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  a wet macular degeneration and a form of blindness
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  after long term use, especially in diabetics and
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  older adults. So if you are diabetic or you are
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  an older adult, get your eyes checked.
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  >> Dr. Terry Simpson: If you're on these medications now, that's not
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  fear, that's follow up.
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  Now let's talk about some benefits that.
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  >> Dr. Terry Simpson: Are more than just a smaller pant size.
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  The select trial showed that there are fewer heart attacks
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  and fewer strokes. Other studies have shown
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  that blood sugar is under better control. There's less
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  liver fat, there is reduced
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  inflammation. Other studies have shown that it is
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  an effective treatment for obstructive sleep apnea.
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  Other studies have shown that it improves kidney function.
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  Others have suggested a lower dementia risk,
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  especially when combined with statins.
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  >> Dr. Terry Simpson: Now, do you want to supercharge your GLP1
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  experience, go Mediterranean?
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  >> Dr. Terry Simpson: No, I don't mean go to the.
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  >> Dr. Terry Simpson: Mediterranean, although I think that's a perfectly good
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  idea.
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  >> Dr. Terry Simpson: But studies show that people on GLP1s who
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  follow a Mediterranean style diet lose
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  more weight than those who just inject in coastal. The
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  original studies done on GLP1s done on these patients,
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  they all were given a Mediterranean style diet to follow,
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  and.
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  >> Dr. Terry Simpson: Some were given placebo and some were given GLP1s.
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  >> Dr. Terry Simpson: Those who followed that do better. When we study
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  people who are not.
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  >> Dr. Terry Simpson: Following any sort of a diet, we find
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  they just don't do as well.
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  >> Dr. Terry Simpson: As those on the original study. So we're talking more
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  vegetables, more legumes, more nuts.
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  We're talking olive oil instead of butter. We're talking
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  fatty fish instead of processed meat.
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  So why does the Mediterranean diet work to support this?
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  >> Dr. Terry Simpson: Well, number one, Mediterranean diet, as you.
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  >> Dr. Terry Simpson: Know, has a decreased risk of all of those diseases. We're worried
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  about obesity, diabetes, cardiovascular disease,
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  strokes, cancers and dementia. And
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  number two, because Mediterranean diet is rich in
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  fibrous food, it helps support.
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  >> Dr. Terry Simpson: Your gut, your gut, hormones, and even.
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  >> Dr. Terry Simpson: Your body's own natural GLP one response.
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  Now, the Mediterranean diet has the advantage of it's not just
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  food in the.
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  >> Dr. Terry Simpson: Mediterranean, it's food you can get anywhere.
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  >> Dr. Terry Simpson: The Mediterranean diet is not about restriction. And
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  this is about synergy.
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  >> Dr. Terry Simpson: You know, the real problem is stigma.
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  >> Dr. Terry Simpson: It's not fat. Obesity is
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  not a character flaw.
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  >> Dr. Terry Simpson: It is a chronic disease.
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  >> Dr. Terry Simpson: The American Medical association declared it a chronic
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  disease in 2013. And the science has
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  been clear about this for years.
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  >> Dr. Terry Simpson: It involves genetics, hormones, gut
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  microbiota, brain.
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  >> Dr. Terry Simpson: Signaling, and the environment.
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  >> Dr. Terry Simpson: It's not just about your fork and your discipline.
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  >> Dr. Terry Simpson: Yet we still get insurance denials.
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  Predominantly we get insurance denials because
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  the medicines are too expensive. In the United States,
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  we have doctors who shame patients instead of
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  treating patients. We have celebrities who
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  lie about their use. And, uh, we have
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  biohacking bros who have no medical license peddling
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  shortcuts that don't work. Obesity
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  treatment needs medicine or surgery. Not
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  moralizing, not magnesium and not
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  misinformation. GLP1s aren't
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  a miracle, but they are the start of a metabolic revolution.
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  They work by quieting the noise in your brain, not
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  just your belly. And when paired with a Mediterranean
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  diet, real medical supervision and a little science.
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  >> Dr. Terry Simpson: Backed support, you've got something powerful.
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  Please check the blog associated with this
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  episode@yourdoctorsorders.com and4q.com
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  this episode was researched and.
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  >> Dr. Terry Simpson: Written by me, Dr. Terri Simpson. And while I am a board certified.
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  >> Dr. Terry Simpson: Physician, I am not your physician. If you're on a
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  GLP1 journey, check.
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  >> Dr. Terry Simpson: Often with your doctor before making any changes. And with the
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  registered dietitian associated with your program.
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  Please don't check with a chiropractor, Eastern.
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  >> Dr. Terry Simpson: Trained shaman who can't even prescribe these medications.
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  Check in often with your physician, get monitored,
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  stay engaged. Support groups
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  help people lose weight and keep on
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  track.
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  >> Dr. Terry Simpson: All things distribution and audio were handled by my friends at
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  Simpler Media.
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  >> Dr. Terry Simpson: And the pod got himself my good buddy, Mr.
• 10:17
  Evotera. Have a good week everybody.
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  >> Dr. Terry Simpson: Hey Evo, I think these drugs are.
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  >> Dr. Terry Simpson: Going to be the source of the next Nobel Prize.
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  >> Dr. Terry Simpson: They are absolutely amazing and revolutionary in what they can do
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  for people. Amazing.
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  >> Dr. Terry Simpson: Have a good week, buddy.
• 10:38
  >> Speaker C: Wait, I thought the next peace prize was going to the felon
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  in chief anyhow. Uh, you my friend,
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  should win a comedy award for that line if your
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  diet is air. And regret
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  I lulled.