Liver Lineup: Innovations in Cholestatic Disease Management, With Kris Kowdley, MD
In this episode of Liver Lineup: Updates & Unfiltered Insights, host Nancy Reau, MD, sits down with Kris Kowdley, MD, to discuss evolving approaches in cholestatic liver disease, with a particular focus on primary biliary cholangitis (PBC).
Key episode timestamps:
0:00:00 – Guest intro & evolution of PBC therapy
0:07:34 – Redefining biochemical response & earlier assessment
0:16:26 – OCA withdrawal & positioning PPARs/fibrates
0:22:16 – Diagnosing AMA‑negative PBC
0:25:58 – Genetic cholestasis panels & PFIC spectrum
0:29:45 – Symptom burden, pruritus, & IBAT inhibitors
0:35:17 – Bone health &…
The skinny
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