328-A Whole-Brain Circadian Atlas of Neural Activity
The paper provides an overview of a research article detailing the creation of a whole-brain, single-cell atlas of circadian neural activity in mice. Researchers used tissue clearing and c-Fos immunostaining over a two-day time series to map the temporal dynamics of spontaneous neural activity across 642 anatomically defined brain regions. The study found that 79% of these regions exhibit significant circadian rhythmicity, with different brain areas, especially those related to sleep-wake cycles, reward, and sensory functions, peaking in activity at diverse circadian times. This comprehensive…
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