376: MCAS, men & women’s health: understanding triggers, disease, calming mast cells & restoring balance

The Natural Alternative - with Madonna Guy · May 28, 2026 · 59m

Madonna Guy and David Sheil explored Mast Cell Activation Syndrome (MCAS) as a key driver behind the surge in metabolic, hormonal and neurological issues now being recognised under the updated term metabolic reproductive syndrome. They discussed how mast cells act as immune sentinels throughout the body — reacting to stress, toxins, infections, chemicals, foods and environmental triggers. When these cells become overactive, they can disrupt hormones, metabolism, gut function, mood, pain pathways and reproductive health. Their conversation highlighted how rising toxin exposure, glyphosate…