1387-Microglial Vascular Pruning via the PD-1 Signaling Axis
The article explores the biological mechanisms behind cerebrovascular pruning, the process by which redundant blood vessels are removed to refine the brain's vascular network. Scientists discovered that microglia, typically known for immune defense and synaptic maintenance, directly facilitate this remodeling by physically interacting with and eliminating unnecessary cortical capillaries. This specialized activity is primarily governed by the PD-L1–PD-1 signaling axis, which regulates microglial phagocytic capacity and their ability to target specific vessels. Experiments revealed that a…
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