759-Logic-Gated Engagers Enhance Macrophage Killing

Paper Talk · Apr 7, 2026 · 22m

This Nature Biotechnology article introduces a novel trispecific macrophage engager (TrME) designed to overcome the limitations of current cancer immunotherapies in solid tumors. The researchers developed a molecular "AND" logic gate that simultaneously activates the prophagocytic LRP1 receptor and blocks the inhibitory SIRPα receptor on the same macrophage. By utilizing computationally guided design and a specialized chimeric linker library, the team identified an optimal configuration for stable cis-targeting, which ensures these dual signals are coordinated within a single immune cell. To…