300-Selection Gene Drives Combat Tumor Drug Resistance
The article introduces a novel genetic engineering approach called selection gene drives to proactively combat the challenge of drug resistance in cancer treatment. This system is designed to redirect tumor evolution by modifying cancer cells with a dual-switch genetic circuit. The first switch provides a controllable fitness advantage under targeted therapy, promoting the engineered cells' expansion, while the second switch is a therapeutic payload that, when engaged, eliminates both the engineered and native drug-resistant cells via a bystander effect. Through the use of stochastic and…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.