1533-Principles of Human&Bacterial Antiviral Immunity
Research indicates that antiviral immunity is a universal characteristic of cellular life, with many human immune components originating billions of years ago in bacteria. These shared systems, such as cGAS-STING and inflammasomes, follow a common strategic framework involving pathogen recognition, signal amplification, and effector functions. While humans often use these pathways for innate immunity to protect multicellular structures, bacteria employ them as a last-resort defense against bacteriophages. Both kingdoms utilize nucleotide signaling and supramolecular complexes to trigger…
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