453-Fatty Acid Recognition by Olfactory Receptors

Paper Talk · Jan 31, 2026 · 18m

This research article describes the structural basis and activation mechanism of class II olfactory receptors, specifically focusing on Olfr110. By utilizing cryo-electron microscopy, the authors identified a large, hydrophobic binding pocket that allows these receptors to detect unsaturated fatty acid metabolites like PL45 and 12(S)-HEPE. The study reveals a dual-pocket architecture and a specialized aromatic residue array that facilitates the recognition of complex, nonpolar odorants common in terrestrial environments. Furthermore, the findings highlight an unconventional activation pathway…