1629-UPEC Invasion of Luminal Prostate Cells
This research study identifies how uropathogenic Escherichia coli (UPEC) infects the prostate by developing a novel 2D organoid-based model that accurately mimics the organ's epithelial diversity. The authors discovered that these bacteria specifically target and multiply within luminal prostate cells, a process driven by the bacterial adhesin FimH. Through molecular analysis and gene knockouts, the team identified prostatic acid phosphatase (PPAP) as the specific host receptor that FimH binds to for cellular entry. Experimental results showed that D-mannose can effectively disrupt this…
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