168-Mapping the Plasma Metabolome to Human Health
This paper presents a comprehensive human metabolome-phenome atlas created by mapping plasma metabolic profiles to a vast array of human diseases and traits. Utilizing data from 274,241 UK Biobank participants with a median follow-up of nearly 15 years, the researchers systematically analyzed over 1.4 million associations between 313 plasma metabolites and thousands of diseases and traits. The study reveals key metabolic alterations occurring more than a decade before disease onset and employs machine-learning-based metabolic risk scores (MetRS) for favorable disease classification and…
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