1628-Spatial Landscapes of Sporadic/Alzheimer’s Disease
This scientific article explores the molecular landscape of Alzheimer’s disease (AD) by comparing its sporadic form with the genetic version found in individuals with Down syndrome. Researchers employed spatial and single-nucleus transcriptomics to map gene expression changes across different layers of the human brain and an amyloid mouse model. The study identified a specific glial inflammatory signature linked to genetic risk that appears in the upper cortical layers during disease progression. By integrating cross-species data, the authors uncovered shared and distinct transcriptomic…
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