429-Securin-Independent Regulation of Separase by SGO2
This research identifies shugoshin 2 (SGO2) as a critical, direct inhibitor of separase in human cells, functioning through a previously unknown pathway controlled by the spindle assembly checkpoint (SAC). While the protein securin was long considered the primary regulator of chromosome segregation, these findings reveal that SGO2 can functionally replace it by binding to MAD2 to block the active site of separase. The study demonstrates that SGO2 acts as a competitive pseudosubstrate inhibitor, effectively mimicking securin's mechanism to prevent premature sister chromatid separation…
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