1024-GATOR1 Complex role in MYC-Driven Lymphomagenesis

Paper Talk · May 24, 2026 · 21m

Researchers utilized an in vivo CRISPR/Cas9 genome-wide screen to identify genes that prevent the development of Myc-driven lymphoma. The study discovered that the GATOR1 complex, consisting of the proteins NPRL3, DEPDC5, and NPRL2, acts as a critical tumor suppressor by regulating the mTORC1 signaling pathway. Deleting any of these components significantly accelerates cancer growth in mice, matching the impact of losing the well-known suppressor p53. Notably, lymphomas lacking GATOR1 function become addicted to hyperactive mTORC1, making them exceptionally vulnerable to treatment with mTOR…