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Dr. Jason Mouabbi & Dr. Michelina Cairo - Talking DB04 and DB06
What happens when an MD Anderson breast oncology investigator Dr. Mouabbi sits down with a high-volume community oncologist Dr. Cairo, who now treats the same patients the trials were written for? Over one fast-moving hour, they chart the collapse of the old HER2 binary, weigh DESTINYBreast 04 against 06, and admit that practicing oncologists still hesitate to jump straight from endocrine therapy to trastuzumab deruxtecan (TDXd) when trusty capecitabine is sitting on the shelf.
They swap war stories about persuading pathology to report “ultralow” staining, debate whether any historical 1+…
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