1122-Patient-Derived Xenograft Models in Cancer Therapy

Paper Talk · Jun 13, 2026 · 26m

This paper is a comprehensive overview of Patient-derived xenograft (PDX) models, a sophisticated preclinical tool where human tumor tissues are transplanted into mice to study cancer therapy. Unlike traditional cell lines, PDX models accurately replicate intratumor heterogeneity, the complex spatial architecture of tumors, and the specific genomic features of individual patients. The text explains how these models are established using immunocompromised or humanized mice to facilitate research into chemotherapy, targeted therapy, and immunotherapy. By integrating modern technologies like…