458-Olfr110 Signaling and Hepatic Glucose Homeostasis
This research identifies Or5v1/Olfr110 as a specific olfactory receptor outside the nose that functions as a critical lipid sensor in the liver and adipose tissue. Scientists discovered that the omega-3 fatty acid derivative 12(S)-HEPE, which increases with exercise and fish oil consumption, activates this receptor to improve glucose metabolism and reduce obesity. The study details how this activation triggers a signaling pathway involving ATF2 and Cpt1α to enhance fatty acid oxidation and metabolic health. Conversely, a deficiency in this receptor is linked to higher Body Mass Index and…
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