How One Hospital Cut Sepsis Mortality 53 Percent With a Single Decision Rule

The Operator's Manual with Fexingo: Daily Decisions, Tactical Wins, and Business Execution · Jul 3, 2026 · 8m · transcript

In this episode of The Operator's Manual, Lucas and Luna examine a single decision rule that slashed sepsis mortality at a large academic medical center. They reveal how the hospital combined a simple qSOFA bedside assessment with a mandatory consult trigger, cutting deaths from sepsis by over half within 18 months. The hosts break down the specific criteria, the implementation challenge with physicians, and the surprisingly low-tech solution that saved hundreds of lives. They also discuss why this approach hasn't been universally adopted despite the data, and how the same logic…