426-Dendritic Cells Orchestrate Innate-Adaptive Trade-offs

Paper Talk · Jan 24, 2026 · 17m

This research identifies dendritic cells (DCs) as the primary architects governing the transition between immediate and long-term immunity within lymph nodes. Upon infection or vaccination, resident DCs rapidly recruit innate effector cells like neutrophils and monocytes by secreting chemokines and expressing the adhesion molecule ICAM-1. While this influx creates an essential innate cell firewall to contain pathogens, a heavy accumulation of neutrophils can temporarily disrupt lymph node architecture and suppress T cell activation. To resolve this, DCs and recruited monocytes eventually…