391-Modeling Brain Dysconnectivity in Rodents

Paper Talk · Jan 12, 2026 · 15m

This review article examines the use of rodent fMRI as a vital tool for understanding brain dysconnectivity in human psychiatric and neurological disorders. While human imaging identifies atypical connectivity patterns, it cannot easily reveal the biological mechanisms or cellular origins of these deficits. By utilizing animal models, researchers can bridge this gap through causal manipulations, such as genetic modifications and neuromodulatory system interventions. The authors highlight the significant spatiotemporal homologies between rodent and human brain networks, which validates the…