334-Modelling late gastrulation in monkey embryo models
The paper describes a breakthrough in modeling primate embryonic development by creating stem cell-derived monkey embryoids that successfully reach the late gastrulation stage (equivalent to Carnegie Stage 8-9). Using an optimized 3D suspension culture system, researchers generated these embryoids from naive pluripotent stem cells and maintained them for up to 25 days, observing key developmental milestones like the formation of the neural plate, primitive gut, and hematopoietic system. Through extensive single-cell transcriptomic analysis and morphological studies, the resulting embryoids…
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