1111-Dietary sulfur amino acids enhance anti-tumor immunity

Paper Talk · Jun 11, 2026 · 24m

This research demonstrates that dietary sulfur amino acids (Saa) significantly bolster anti-tumor immunity in colon cancer by modulating the gut microbiome. Through a meta-analysis of human data and experiments in mouse models, the authors found that a high-Saa diet induces a bloom of the mucus-dwelling bacterium Mucispirillum schaedleri. This microbial expansion triggers natural killer T (NKT) cells to secrete the chemokine XCL1, which is essential for recruiting and activating type 1 conventional dendritic cells (cDC1s). These activated dendritic cells then enhance the presence of cytotoxic…