355-Paneth-like Transition Drives Cancer Resistance
This research identifies a Paneth-like cell transition as a primary driver of non-genetic resistance to combined KRAS and EGFR inhibition in colorectal cancer (CRC). By utilizing genetically engineered mouse models and patient-derived organoids, the authors demonstrate that CRC cells adopt a secretory lineage state to evade therapeutic pressure and reactivate MAPK signaling. The study reveals that the SMAD1-FGFR3 signaling axis orchestrates this cellular plasticity and lineage switch. Importantly, the researchers found that pharmacological or genetic inhibition of FGFR3 effectively blocks…
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