734-The Tumor Microbiota
Recent research identifies diverse microbial communities residing within tumors, even in organs far from the gut, that significantly influence cancer progression and treatment outcomes. This commentary establishes a formal definition for the tumor microbiota, encompassing various microorganisms and their metabolites located physically within the tumor environment. The authors emphasize that these microbes can reprogram host cells, affecting hallmarks like metastasis, immune evasion, and drug resistance. To address technical challenges such as low-biomass contamination, the text advocates for…
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