370-Metabolic Stress Priming in Hepatocarcinogenesis
This research explores how long-term metabolic stress transforms the liver, focusing on the cellular shift from healthy function to chronic disease and cancer. By utilizing multi-omic technologies and spatial transcriptomics in both mice and humans, the authors identify specific gene programs that regulate hepatocyte behavior during the progression of MASLD and cirrhosis. The study introduces MATCHA, a computational tool designed to uncover the transcription factors, such as RELB and SOX4, that drive these pathological changes. These molecular regulators are found to increase cellular…
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