1187-Mitochondrial Interaction with Nuclear Pore Complex
This research identifies a physical connection between mitochondria and the nuclear pore complex mediated by the interaction of the proteins RANBP2 and VDAC1. Using advanced imaging and proteomic screens, scientists discovered that this direct contact acts as a metabolic tether essential for efficient energy transfer to the nucleus. Experimental disruption of this link led to a significant drop in nuclear ATP and phosphocreatine levels, which subsequently impaired nuclear phosphorylation and transcriptional regulation. These energetic deficits were found to hinder cellular differentiation in…
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