1569-cMAF Program in Brain Perivascular Macrophages
This scientific research identifies the transcription factor cMAF as the essential regulator of brain perivascular macrophages in both mice and humans. These specific immune cells are located along cerebral arteries, where they utilize a cMAF-dependent program to produce IGF1, a signaling molecule that sustains healthy blood flow and cerebrospinal fluid circulation. When cMAF is deleted, these macrophages lose their specialized identity, leading to vascular dysfunction and impaired physiological responses. The study further reveals that this molecular crosstalk is disrupted in Alzheimer’s…
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