1469-IL17RA Recognition and the Development of Vδ7 γδT Cells

Paper Talk · Aug 21, 2026 · 25m

1 source·Aug 10, 2026

This research identifies interleukin 17 receptor A (IL17RA) as a novel, direct ligand for the Vδ7 γδTCR in mice, a discovery that clarifies long-standing mysteries regarding γδT cell antigen recognition. Using cDNA library screening and surface plasmon resonance, the authors demonstrate that IL17RA interacts with germline-encoded regions of the Vδ7 chain rather than traditional CDR3 loops. This nonclonotypic interaction is essential for the development and survival of a major population of TH1-like effector γδT cells found in secondary lymphoid organs. The study proves…