578-A Single-Cell Atlas of Embryonic Endothelial Development

Paper Talk · Mar 3, 2026 · 17m

This research introduces the STED-EC atlas, a comprehensive single-cell transcriptomic resource mapping endothelial cell (EC) development across eight major organs during mouse embryogenesis. By analyzing these cells at half-day intervals, the authors identified that organ-specific vascular features primarily emerge during the mid-gestational stage. A comparison between mouse and human lung data revealed both evolutionary similarities and distinct gene expression patterns, highlighting the complexity of vascular specialization. The study specifically identifies the transcription factor Casz1…