Heterogeneity in Primary CNS Vasculitis

Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology · May 18, 2026 · 10m

This study analyzes a forty-year cohort of 216 patients at the Mayo Clinic to examine the diverse presentations and clinical outcomes of primary central nervous system vasculitis (PCNSV). The research identifies that vessel size and histopathologic patterns are the primary drivers of disease heterogeneity, distinguishing between small vessel involvement and medium or large vessel disease. Patients with small vessel disease frequently present with cognitive issues and have better treatment responses, while large vessel involvement is linked to more frequent strokes and a rapidly progressive…