743-Mechanotransduction in the Nucleus

Paper Talk · Apr 4, 2026 · 24m

This article explores how the cell nucleus perceives and reacts to physical environmental pressures, a process known as mechanotransduction. It details the structural components that facilitate these responses, including the nuclear envelope, LINC complexes, and chromatin, which together govern nuclear stability and gene expression. The authors describe how external stressors can trigger transcriptional changes or, in extreme cases, lead to DNA damage and genomic instability. Furthermore, the text highlights the connection between mechanical malfunctions and various pathologies such as…