Desmoid Tumors | Oncology Today with Dr Neil Love: Management of Desmoid Tumors

Research To Practice | Oncology Videos · Feb 28, 2023 · 54m

Featuring perspectives from Dr Mrinal Gounder, including the following topics:

• Incidence and prevalence of desmoid tumors (00:00)

• Outcomes associated with historical management paradigms for desmoid tumors (17:15)

• Rationale for targeting the gamma secretase complex and Notch pathway as a therapeutic approach for desmoid tumors; mechanism of action of nirogacestat (20:56)

• Key efficacy outcomes from the Phase III DeFi trial evaluating the gamma secretase inhibitor nirogacestat versus placebo for progressing desmoid tumors (30:14)

• Spectrum and frequency of adverse events, including…