Lymphoma | What Clinicians Want to Know About the Current and Future Role of EZH1/2 Inhibitors in the Care of Patients with Lymphoma

Research To Practice | Oncology Videos · Nov 8, 2024 · 56m

Featuring an interview with Dr Gilles Salles, including the following topics:

Epigenetic modifications and the role of EZH2 in the pathobiology of follicular lymphoma (FL) (0:00)

Natural history of FL and current treatment landscape in the first-line setting (5:20)

Testing approaches for the detection of EZH2 mutations (14:37)

Mechanism of action of the EZH inhibitors tazemetostat and valemetostat (18:31)

Tazemetostat monotherapy as treatment for relapsed/refractory FL (20:58)

Ongoing evaluation of novel treatment approaches with tazemetostat for FL and other lymphomas (25:31)

Approved…