1529-Neural Circuit for Compulsive Eating
This research identifies a specific cortical-hypothalamic neural circuit that governs compulsive eating behaviors. By studying both mice and humans, scientists discovered that neurons in the medial prefrontal cortex (mPFC) communicate with the rostral zona incerta (rZI) to drive food-seeking even when faced with negative consequences. In animal models, stimulating this pathway led to persistent bingeing that was resistant to punishment, while human brain imaging revealed that stronger connectivity between these regions correlates with obesity and binge-eating traits. Unlike other…
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