490-Peroxisome-Mediated Intestinal Repair in Long COVID
SARS-CoV-2 reservoirs in the gut cause long COVID gastrointestinal issues by disrupting the VLCFA-PPAR-peroxisome axis. This impairment halts intestinal stem cell differentiation and epithelial repair. Treatments like fenofibrate restore regeneration and alleviate symptoms.
References:
Wang M, Chen Y, Guo M, et al. Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID[J]. Developmental Cell, 2026.
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