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The Drug That Made Animals Trip - Humans Couldn't Stomach It
The Drug That Made Animals Trip - Humans Couldn't Stomach It
Quipazine produced head-twitches and full drug-discrimination substitution in rodents and monkeys, yet in humans even 25 mg caused vomiting and intolerable gastrointestinal distress-could a molecule that clearly acted like a psychedelic in animals ever be tested safely in people?
In this episode, we trace quipazine’s six-decade arc from a 1966 antidepressant candidate to a legal, unscheduled compound that elicited LSD-like signatures in animals but failed every human escalation; can the gap between animal signals and human…
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