1143-Spatial Heterogeneity of Triple-Negative Breast Cancer
This study utilizes spatial transcriptomics to analyze the complex internal structure and microenvironment of triple-negative breast cancer (TNBC). By examining 92 patients, researchers identified that traditional molecular classifications often overlook significant intratumoral heterogeneity and the critical role of the stroma in disease progression. A major finding is the development of a 30-gene signature for tertiary lymphoid structures (TLS), which serves as a powerful predictor of positive immunotherapy response and overall survival. The team further categorized the TNBC ecosystem into…
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