Neurologic Adverse Events from Immune Checkpoint Inhibitors

Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology · May 31, 2026 · 20m

Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment, but they can trigger a wide range of neurological immune-related adverse events (irAE) by disrupting immune tolerance. These complications affect both the central and peripheral nervous systems, often manifesting with rapid progression and significant risks of disability or death. A particularly critical condition highlighted is Triple M syndrome, which involves the life-threatening triad of myasthenia, myositis, and myocarditis. Diagnostic challenges arise because these events often present with atypical symptoms…