1326-Metabolomic Refine Metabolic Risk Stratification
The paper details a large-scale study of over 13,000 older adults that utilizes metabolomics and machine learning to redefine metabolic health beyond traditional Body Mass Index (BMI) categories. By analyzing 39 core metabolites, researchers developed a BMI-metabolic health score (BMHS) that accurately identifies metabolic dysfunction and independently predicts cardiovascular and all-cause mortality. The study highlights how specific metabolic pathways, such as taurine and choline metabolism, vary across different weights and how a high-risk BMHS significantly influences long-term prognosis…
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