1530-Circadian Regulation of OPC Metabolism in Aging
The research identifies the circadian transcription factor BMAL1 as a vital regulator of metabolic health and cellular aging within oligodendrocyte precursor cells (OPCs). Aging and multiple sclerosis (MS) cause BMAL1 dysfunction, which triggers a cascade of mitochondrial defects, metabolic imbalances, and cellular senescence that ultimately impairs myelin repair. By utilizing evening-timed chronotherapy with sirtuin-activating drugs like metformin, the researchers successfully rejuvenated dysfunctional OPCs and improved remyelination in mouse models. Similar disruptions in circadian…
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