467-Proteogenomic Landscape of Gallbladder Cancer
This research presents a comprehensive proteogenomic analysis of gallbladder cancer (GBC) to uncover the molecular drivers of its high mortality and clinical diversity. By integrating genomic, transcriptomic, and proteomic data, the authors identified four distinct molecular subtypes and four immune microenvironment profiles that correlate with patient prognosis and drug sensitivity. A key discovery involves the role of metabolic reprogramming, specifically through proteins like ACAT1 and PHGDH, in fueling the liver invasion that characterizes advanced disease. The study also explores the…
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