718-SelO Regulates Mitochondrial Homeostasis

Paper Talk · Mar 30, 2026 · 18m

This research identifies SelO as a conserved mitochondrial enzyme that regulates energy metabolism by hydrolyzing NAD+ into NMN and AMP. Using structural analysis of the bacterial homolog ydiU, scientists discovered that this activity is driven by a unique C-terminal selenocysteine residue and is triggered by increases in mitochondrial pH. The study demonstrates that SelO directly associates with fatty acid oxidation enzymes, effectively acting as a metabolic brake to prevent overactivation. In mice, the absence of this enzyme leads to elevated mitochondrial NAD+ levels and increased lipid…